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In enzymology, a D-3-phosphoglycerate dehydrogenase () is an enzyme that catalyzes the chemical reactions :3-phospho-D-glycerate + NAD+ 3-phosphonooxypyruvate + NADH + H+ :2-hydroxyglutarate + NAD+ 2-oxoglutarate + NADH + H+ Thus, in the first case, the two substrates of this enzyme are 3-phospho-D-glycerate and NAD+, whereas its 3 products are 3-phosphohydroxypyruvate, NADH, and H+; in the second case, the two substrates of this enzyme are 2-hydroxyglutarate and NAD+, whereas its 3 products are 2-oxoglutarate, NADH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. In humans, this enzyme is encoded by the ''PHGDH'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26227 )〕 == Function == 3-Phosphoglycerate dehydrogenase (PHGDH; EC 1.1.1.95) catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.〔 Certain breast cancers are dependent on the overexpression of PHGDH. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「phosphoglycerate dehydrogenase」の詳細全文を読む スポンサード リンク
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